Gender Separation Increases Somatic Growth in Females but Does Not Affect Lifespan in Nothobranchius furzeri
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Gender Separation Increases Somatic Growth in Females but Does Not Affect Lifespan in Nothobranchius furzeri
According to life history theory, physiological and ecological traits and parameters influence an individual's life history and thus, ultimately, its lifespan. Mating and reproduction are costly activities, and in a variety of model organisms, a negative correlation of longevity and reproductive effort has been demonstrated. We are employing the annual killifish Nothobranchius furzeri as a vert...
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Evolutionary theories of senescence postulate that lifespan is determined by the age-dependent decrease in the effects of natural selection. Factors that influence survival and reproduction at early life stages have a larger impact on fitness than factors that influence later life stages. According to these views, selection for rapid sexual maturation and a steep age-dependent decrease in fitne...
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Neurodegeneration has diverse molecular causes. α-synucleinopathies are implicated in at least three neurodegenerative diseases: Parkinson’s Disease, Dementia with Lewy bodies and Multiple System Atrophy. Age-related increases in α-synuclein and its oligomers have been observed in short-lived Nothobranchius furzeri. N. furzeri Gonarezhou, with a lifespan of 9–12 weeks, is a new model organism f...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0011958